ピル
rx no.007· myths· 004 tolerance

a tolerance myth ・ multi-layer kinetics

A break doesn't reset you.
It resets you in layers.

Tolerance isn't one thing on one clock. Your receptors adapt in days, the signaling behind them in weeks, and the deep wiring in months — all at once, at different speeds. So when the same dose stops working, a few days off brings back the fast part and fools you into thinking you've reset. You haven't. Watch what a break actually does.

Fast
receptors · back in days
Medium
signaling · back in weeks
Deep
plasticity · back in months
30 days
7 days

This is Piru's real three-layer tolerance engine — per mechanism class, each with its own build and recovery clock. It's why Piru can tell you a break is working and that you're not there yet. See your own tolerance →

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