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rx no.007· myths· 003 grapefruit

a medication myth ・ CYP3A4

A glass of juice can turn one pill into three.

Your gut lining is packed with an enzyme (CYP3A4) whose job is to destroy most of a drug before it ever reaches your blood. Grapefruit shuts that enzyme down — so the same pill sails through and hits like a much bigger dose. It's real, it's dramatic, and it's oddly specific. Pick a medication and pour.

normalwith grapefruit
🍊 grapefruit juice this morning

Piru models this as a real CYP3A4 interaction, per-drug — it knows which of your meds grapefruit touches and which it doesn't. See your own interactions →

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